Sentra Biosains Dinamika

ViennaLab - SLCO1B1c.521T>C RealFast™ Assay

Catalog No. 7-210 / 7-213 Category

Statins are used in the treatment of hypercholesterolemia, but can cause severe side effects. The SLCO1B1 c.521T>C RealFast™ Assay identifies a genetic variant responsible for simvastatin-induced myopathy.


  • Simvastatin is a widely prescribed statin for lowering LDL cholesterol levels, but may cause dose-dependent adverse events.
  • The c.521T>C variant of the solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene affects the hepatic uptake and metabolism of statins.
  • Patients carrying the c.521C allele have a higher risk of simvastatin-induced myopathy and rhabdomyolysis.
  • Adjustment of simvastatin dose according to the SLCO1B1 c.521T>C genotype is recommended by the Clinical Pharmacogenetic Implementation Consortium (CPIC).

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